PTAInterspecies DosePharmTech Archive한국어

IN VIVO · REVERSE FIXED-km BSA

Human to Animal
Dose Calculator

Estimate a BSA-equivalent animal dose by algebraically reversing the fixed-km conversion.

Formulaanimal mg/kg = human mg/kg × 37 / animal km
1

Human designated dose

2

Target animal

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Use the calculated mg/kg dose to determine working concentration and administration volume. Values are not transferred automatically.

Scope, limitations, and references

Scope and limitations

Fixed-km BSA scaling is a simplified interspecies estimate, not a recommended or experimentally validated dose. It does not account for species-specific pharmacokinetics, bioavailability, administration route, dosing frequency, pharmacodynamics, efficacy, or toxicity. It may be inappropriate for locally acting or compartmental administration, marked route-dependent bioavailability, large biologics, or compounds with major interspecies PK/PD differences.

This algebraic reverse-scaling estimate does not represent a recommended dose for an animal model.

References

FDA — Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers (km table and reference weights)

Nair & Jacob — A simple practice guide for dose conversion between animals and human (reverse animal-equivalent relationship)